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William Hughes - Stockholm University

To identify coding genetic variants associated with these traits, we conducted meta-analyses of seven RBC phenotypes in 130,273 multi-ethnic individuals from studies genotyped on an exome array … 2020-08-27 Pleiotropy - refers to one gene influencing many traits. Example: If one gene determined two traits that were different from one another. Making up an easy example it could be one gene determines both hair colour and length of claws in cats. Polyg Pleiotropic genes affect what appear to be unrelated aspects of phenotype, though usually there is a biochemical or regulatory explanation to be found.

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2017-07-25 · Thus, the trait in the offspring is a mixture of parental traits. The external environmental factors also have an effect on polygenic inheritance. Most of the metric and meristic traits are under the influence of polygenic inheritance. The polygenic traits exhibit a continuous distribution in a population.

It is often difficult to detect which traits may be the result of pleitoropy unless a mutation occurs in a gene. Pleiotropy describes the genetic effect of a single gene on multiple phenotypic traits. The underlying mechanism is genes that code for a product that is either used by various cells or has a cascade-like signaling function that affects various targets.

Publications 1. Peer reviewed papers 96 de Manzano Ö

^ Roff (1990) Antagonistic pleiotropy and  Frizzled Feather Trait. Frizzle kycklingegenskap. Denna bild illustrerar aspekter av fenotypen för frizzle-kyckling.

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cognitive transfer within the framework of music practice: Genetic pleiotropy rather than causality. Dev Sci Personality and related traits as predictors of music  among traits determining migratory tendency in the sand cricket, Gryllus firmus, Evolution 44(7):1787-1795, illustr. ^ Roff (1990) Antagonistic pleiotropy and  Frizzled Feather Trait.

Polledness in beef and dairy cattle: inheritance and impact on other traits Om detta är ett resultat av låg selektionsintensitet eller om det beror på genetisk  approach (cross-trait meta-analysis, functional annotation, enrichment analysis, etc.) to understand relationship, novel loci and pleiotropic mechanisms across  Shared signaling pathways utilized by melanocytes and neurons result in pleiotropic traits of coat color and behavior in many mammalian species. For e. 5.
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Pleiotropic traits

Models for the origin As stated, pleiotropy is where one gene winds up controlling multiple phenotypic traits in the organism. Pleiotropy can be found in many different forms, but mainly it is viewed as causing By definition, pleiotropy is a situation in which one gene controls for the expression of multiple phenotypic traits. These traits don’t have to be clearly linked, i.e., eye shape and eye color, but can instead be completely unrelated.

B. Controls a trait only in combination with another gene.
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MeSH: Genetic Pleiotropy - Finto

2018-10-25 2017-04-28 2021-02-08 2011-11-11 As the appreciation of pleiotropic effects has gained traction in the scientific community, cross-disorder analyses of several related traits have been increasingly carried out to disentangle shared and disease-specific genetic determinants [27–30]. Alternatively, even if the pleiotropic gene responds to the same cue in the same manner, it may regulate its downstream partner differently for different traits; for instance, high temperature may upregulate the pleiotropic gene at all life stages, but that gene may upregulate its partner at one life stage but downregulate that same partner at a different stage.

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Most of the metric and meristic traits are under the influence of polygenic inheritance.